Utility of Different Lipids and Effect of Soya Lecithin on Sustained Delivery of Zidovudine via Biodegradable Solid Lipid Microparticles: Formulation and in-vitro Characterization

Abstract: Background: Zidovudine (Azidothymidine, AZT) is widely used in the treatment of Acquired Immuno Deficiency Syndrome (AIDS) and related conditions, either alone or combination with other antiviral agents to combat HIV. AZT a Biopharmaceutical Classification System (BCS) class III drug has various disadvantages. Thus, potential candidate for delivery via lipid-based system. Materials Methods: In present work, solid lipid microparticles (SLMs) were developed sustaining release, overcome reduce hepatic metabolism ensure optimal bioavailability. A total sixteen formulations loaded two groups viz., one tripalmitin another trimyristin prepared by emulsion-solvent evaporation method. Results: The average particle size entrapment efficiency SLM varied between 5.48 μm-10.64 μm 46.92 % 58.39% respectively. release zidovudine from 70.47% 100% at end 24 hrs. 80% which required obtaining therapeutic concentration was achieved 8. Conclusion: Formulation 8 considered best maximum sustainability along maintaining optimum. formulation found stable under stressed conditions. Keywords: Zidovudine, Azidothymidine, AIDS, Solid microparticles, Tripalmitin,Trimyristin.